Raloxifene is a selective estrogen receptor modulator (SERM) that binds to estrogen receptors and mimics some of the effects of estrogen in certain tissues like bone, while blocking the effects of estrogen in other tissues like breast and uterus.
Some key points about raloxifene and testosterone:
- Raloxifene does not directly increase testosterone levels. It works by binding to estrogen receptors and does not have direct effects on testosterone production or pathways.
- However, raloxifene may indirectly increase testosterone levels in some cases by inhibiting estrogen's effects. Estrogen normally signals the body to increase levels of sex hormone binding globulin (SHBG), a protein that binds and inhibits testosterone. By blocking estrogen, raloxifene could potentially decrease SHBG and allow more free, active testosterone.
- The effects on testosterone levels are likely to be modest if present. One small study found no significant difference in testosterone levels in postmenopausal women taking raloxifene versus placebo over 3 years. Larger or longer-term studies may be needed to fully understand raloxifene's impact.
- Raloxifene is mainly used for bone strength and to prevent breast cancer risk in postmenopausal women. Increasing testosterone is not its primary purpose or a proven benefit. The Endocrine Society notes there is insufficient evidence that SERMs can treat low testosterone in women.
So in summary:
Raloxifene does not directly boost testosterone production but may allow more free, active testosterone by decreasing SHBG levels. However, current evidence that it increases testosterone is limited and more research is needed.
If you're concerned about low testosterone,
speak to an endocrinologist for proper testing, diagnosis of the underlying cause, and evidence-based treatment options for your circumstances.
Some signs of low testosterone include:
At
Optimal Hormone Wellness Center, our endocrinologists specialize in properly diagnosing and treating hormonal imbalances with treatments tailored to each patient's medical needs and goals. Schedule a consultation today to discuss options for improving symptoms and quality of life if you suspect hormone issues.
We're here to listen, answer questions, and partner with you on your health journey without judgement.
